Strain: NOD.Cg-Prkdcscid/JInv

Common name: NOD SCID

JAX stock no. 001303


Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Prkdcscid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. In general, Prkdcscid leakiness is low on the NOD/ShiLtSz genetic background.


Disease/therapeutics areas used:

  • Cancer research
    • B and T cell deficiency, xenograft/transplant host
  • Immunology, Inflammation and Autoimmunity Research
    • B and T cell deficiency
  • Internal/Organ Research
    • Lymphoid Tissue Defects
  • Virology Research
    • B and T Cell Deficiency- AIDS research tool
  • Diabetes and Obesity Research
    • Islet Transplantation Studies


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