NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ

NOD scid gamma

CONGENIC, SPONTANEOUS MUTATION, TARGETED MUTATION MICE

OVERVIEW

Also Known As: NOD scid gamma, NOD-scid IL2Rgnull, NOD-scid IL2Rgammanull, NSG

These NSG mice combine the features of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid) and IL2 receptor gamma chain deficiency. As a result, these NSG mice lack mature T cells, B cells, or functional NK cells, and are deficient in cytokine signaling, leading to better engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells than any other published mouse strain. Recent publications have demonstrated this strain’s outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells.

Donating Investigator

Dr. Leonard D. Shultz, The Jackson Laboratory

Detailed description and more details on The Jackson Laboratory website

Appearance

albino

Related Genotype: A/A Tyrc/Tyrc

 

GENETIC OVERVIEW

Genetic Background Generation
N8F?+4pF24
(14-AUG-14)

Il2rgtm1Wjl

Allele Type Gene Symbol Gene Name
Targeted (Null/Knockout) Il2rg interleukin 2 receptor, gamma chain

Prkdcscid

Allele Type Gene Symbol Gene Name
Spontaneous Prkdc protein kinase, DNA activated, catalytic polypeptide

InVivos’ Health Reports can be found here.

Disease Terms

Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.

Research Areas by Genotype

This mouse can be used to support research in many areas including:

  • Research Tools
    • Immunology, Inflammation and Autoimmunity Research
      • B, T, and NK cell deficiency
    • Infectious Disease
      • HIV

Genotype: Il2rgtm1Wjl related

  • Cancer Research
    • Growth Factors/Receptors/Cytokines
  • Immunology, Inflammation and Autoimmunity Research
    • Growth Factors/Receptors/Cytokines

Genotype: Prkdcscid related

  • Immunology, Inflammation and Autoimmunity Research
    • Immunodeficiency
      • B and T cell deficiency
  • Internal/Organ Research
    • Lymphoid Tissue Defects
      • B and T cell deficiency
  • Research Tools
    • Cancer Research
      • B and T cell deficiency, xenograft/transplant host
    • Toxicology Research
      • xenograft/transplant host
  • Virology Research
    • B and T Cell Deficiency
      • AIDS research tool

Further information can be found on The Jackson Laboratory’s Website

 

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