CBA/JInv

CBA Jackson

TRADITIONAL INBRED MICE

Former Names: CBA/J-Pde6brd1    (Changed: 19-MAR-08 )

CBA/J-Mx1s2    (Changed: 19-JUL-07 )

Type: Inbred Strain;

Additional information on Inbred Strains.

Visit the JAX® online Nomenclature tutorial.

Mating System: Sibling x Sibling         (Female x Male)   01-MAR-06

Breeding Considerations: This strain is a challenging breeder.

Species: laboratory mouse

H2 Haplotype: k

Generation: F273pF283 (05-AUG-14)

Generation Definitions

 

Appearance

agouti
Related Genotype: A/A

Important Note

This strain is homozygous for the retinal degeneration allele Pde6brd1. See article “Genetic Background Effects: Can Your Mice See?”, JAX® NOTES Spring 2002, No. 485.

Description

CBA/J inbred mice are widely used as a general purpose strain. CBA/J strain is the only CBA substrain that carries the Pde6brd1 mutation, which causes blindness by wean age. CBA/J mice are not histocompatible with the CBA/CaJ (Stock No. 000654) substrain (Green and Kaufer, 1965).

The CBA/J inbred mouse strain is used to study granulomatous experimental autoimmune thyroiditis (G-EAT), are relatively resistant to diet-induced atherosclerosis (Paigen et al. 1990), and develop a mild hearing loss late in life, with most of the hearing loss occurring in the higher frequencies (Sweet et al. 1988). Renal tubulointerstitial lesions have been observed in this strain at a high frequency (Rudofsky 1978). Some CBA/J mice spontaneously develop exocrine pancreatic insufficiency syndrome (Eppig and Leiter 1977, Leiter et al. 1977).

Development

Beginning in 1920, Strong developed the CBA inbred strain from a cross of an unpedigreed Bagg albino female and an early DBA progenitor male. C3H mice are descended from the same cross. CBA was selected for a low incidence of mammary tumors. Strong sent the CBA mice to Andervont in 1947. Andervont sent the CBA mice to The Jackson Laboratory in 1948.

 

Additional Web Information

JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, January 1988; 432. Arthritis Models in the Mouse.
JAX® NOTES, January 1988; 432. CBA Substrains Maintained at The Jackson Laboratory.
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
Sequence data is available from the Mouse Genomes Project at the Wellcome Trust Sanger Institute

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InVivos’ Health Reports can be found here.

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: CBA
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]

Related Disease (OMIM) Terms provided by MGI

– Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.

Night Blindness, Congenital Stationary, Autosomal Dominant 2; CSNBAD2   (PDE6B)
Retinitis Pigmentosa 40; RP40   (PDE6B)

 

Research Applications

This mouse can be used to support research in many areas including:

Cardiovascular Research
Diet-Induced Atherosclerosis
Relatively Resistant

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
experimental autoimmune thyroiditis

Internal/Organ Research
Kidney Defects
Renal tubulointerstitial lesions

Metabolism Research
Enzyme Deficiency
exocrine pancreatic insufficiency

Research Tools
General Purpose

Sensorineural Research
Hearing Defects
Age related hearing loss
Retinal Degeneration
Homozygous for Pde6brd1

Pde6brd1 related

Sensorineural Research
Retinal Degeneration

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