BALB/cJInv

BALBc

TRADITIONAL INBRED MICE

Type: Inbred Strain;

Additional information on Inbred Strains.

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Mating System: Sibling x Sibling         (Female x Male)   01-MAR-06

Breeding Considerations: This strain is a challenging breeder.

Species: laboratory mouse

H2 Haplotype: d

Generation: F243 (05-AUG-14)

Generation Definitions

 

Appearance

albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description

BALB/c mice are particularly well known for the production of plasmacytomas following injection with mineral oil forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant (see: Potter M ,1985). Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains.

White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted.

Dorso-ventral vaginal septa is observed in some BALB/cJ females, and may contribute to non-productive females in this strain. (Cunliffe-Beamer T, Lab Anim Sci, 1976)

 

Additional Web Information

JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX® NOTES, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX® NOTES, January 1988; 432. Arthritis Models in the Mouse.
JAX® NOTES, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX® NOTES, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX® NOTES, Winter 2002; 488. Colony Expansions Completed for JAX® Mice Strains C57BL/6J and BALB/cJ.
JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
Mouse Phenome Database / SNP Facility
Sequence data is available from the Mouse Genomes Project at the Wellcome Trust Sanger Institute

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InVivos’ Health Reports can be found here.

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: BALB/c
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]

Mammalian Phenotype Terms provided by MGI

assigned by genotype

Hld/Hld

either: BALB/cByJ or BALB/cJ

nervous system phenotype

abnormal dendrite morphology

  • abnormally positioned by being late-generated   (MGI Ref ID J:12029)
  • cell bodies are located below the intrapyramidal mossy fiber layer   (MGI Ref ID J:12029)

abnormal hippocampus morphology   (MGI Ref ID J:13989)

    • abnormal hippocampal mossy fiber morphology   (MGI Ref ID J:12029)
    • abnormal hippocampus CA3 region morphology
      • there is abnormal lamination of this cell layer resulting in superficial early generated neurons and deep late-generated neurons   (MGI Ref IDJ:12029)
    • abnormal hippocampus layer morphology
      • the anomaly is also seen in BALB/cByJ, F1 mice involving BALB sublines noted, and some CXB RI lines; C57BL/6J is considered wild-type for this feature   (MGI Ref ID J:13989)
      • this is secondary to a defect in neuronal migration   (MGI Ref ID J:13989)
      • ectopic hippocampus pyramidal cells
        • located below the intrapyramidal layer; some of the ectopic cells have short, fine-caliber dendritic branches arising near the points of contact of the intrapyramidal mossy fibers   (MGI Ref ID J:12029)

abnormal neuronal migration   (MGI Ref ID J:13989)

cellular phenotype

abnormal neuronal migration   (MGI Ref ID J:13989)

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
Mammary Gland Tumors
Mammary Gland Tumors: late onset

Cardiovascular Research
Diet-Induced Atherosclerosis
Relatively Resistant

Immunology, Inflammation and Autoimmunity Research
Inflammation

Neurobiology Research
Behavioral and Learning Defects
high anxiety
Neurodevelopmental Defects
callosal agenesis, incomplete penetrance

Research Tools
Cancer Research
monoclonal antibodies, myeloma and hybridoma production
General Purpose
Infectious Disease
Anthrax
Salmonella
Tuberculosis (TB)

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